【摘要】 目的研究在卵巢上皮癌中抑癌基因PTEN及凋亡抑制因子Survivin的表达及二者是否相关。方法应用免疫组化SP法,检测PTEN、Survivin蛋白在46例良性上皮性卵巢肿瘤、40例正常卵巢组织、76例上皮性卵巢癌中的表达。结果在卵巢上皮性癌中PTEN蛋白的表达水平明显低于卵巢良性肿瘤及正常卵巢组织,差异有显著性(P<0.05);Survivin蛋白的表达与PTEN蛋白相反,在卵巢上皮性癌中的表达明显高于卵巢良性肿瘤及正常卵巢组织,差异有显著性(P<0.05),两者的表达呈负相关(r=-0.527,P=0.001)。二者的表达与年龄及病理类型无关(P>0.05),与临床分期、分化程度及是否转移相关(P<0.05)。结论 Survivin蛋白及PTEN的表达与卵巢上皮性癌的发生、发展有关;二者的联合检测有助于判断卵巢上皮性癌的恶性程度及预后。更多还原

【Abstract】 Objective To investigate the expression and correlation of PTEN and survivin in ovarian epithelia carcinoma.Methods The expression of PTEN and survivin in 46 cases of benign epithelial ovarian tumor,40 cases of normal ovarian tissue,76 cases of epithelial ovarian cancer were determined by SP immunohistochemical method.Results The positive rate of PTEN in the ovarian carcer tissue was lower than that in the normal and benign ovarian tumors(P<0.05).Survivin expression trend was opposite to that of PTEN.In ovarian epithelia carcinoma,negative correlation between expression of PTEN and survivin was observed(r=-0.527,P=0.001).No different expression of PTEN and survivin among histological types or ages was found(P>0.05).The expression level of PTEN and surviving were associated with differentiation,clinic stage(P<0.05).Conclusion PTEN and survivin may play an important role in the initiation,development of ovarian epithelia carcinoma and the combination of PTEN and survivin expression may be helpful in predicting the malignant degree and prognosis of ovarian epithelia cancer.更多还原