目的:依据临床病理资料对目前国际上使用最广泛的5种术前判断惰性前列腺癌的筛选标准进行探讨,以探索这些标准对国人惰性前列腺癌筛查的有效性。方法:回顾性分析2006年1月至2014年4月,314例于北京大学第一医院行前列腺穿刺活检确诊,并行根治性前列腺切除术的前列腺癌患者的临床病理及手术病理资料。以手术病理Gleason评分≤6、分期T2、癌灶总体积≤0.5 m L作为惰性前列腺癌的病理标准,对比国际上研究较多的5种判断惰性前列腺癌的临床标准,分别为Epstein标准(EC)、Sloan-Kettering纪念肿瘤中心标准(Memorial Sloan-Kettering Cancer Center,MSKCC)、国际前列腺癌研究-主动监测标准(Prostate Cancer Research International:Active Surveillance,PRIAS)、UCSF标准(University of California,San Francisco,UCSF)和UM标准(University of Miami,UM),对灵敏度、特异度以及受试者工作特性曲线下面积(areas under the r...
【英文摘要】
Objective: To compare the diagnostic accuracy of five internationally used indolent prostate cancer screen protocols in Chinese prostate cancer patients. Methods: Retrospective analysis was made of the consecutive cohort of 314 patients,from Jan. 2006 to Apr. 2014,who had both prostate biopsy and radical prostatectomy in Peking University First Hospital. The Gleason score≤6,p T2,tumor volume≤0. 5 m L,margin negative and lymph nodes negative were defined as indolent prostate cancer. The predictive value of f...
△Corresponding author’s e-mail,jinjie@vip.163.com*These authors contributed equally to this work随着前列腺特异抗原(prostate specific anti-gen,PSA)的应用,前列腺癌的筛查诊断在临床广泛开展,越来越多的前列腺癌被发现。不同前列腺癌对健康的影响存在差异,惰性前列