【摘要】 目的:运用数据挖掘的方法,探讨"十八反"药物在临床应用时的组成规律,分析其配伍特点,为"十八反"药物的临床应用提供参考。方法:通过收集华中地区三甲级中医院临床处方,运用关联规则的方法进行数据挖掘,分析药物的配伍特点。结果:该医院"十八反"药物临床应用调查结果显示,该医院临床应用配伍的核心药物为甘草、半夏、附子、干姜、白术、茯苓等,其中半夏的用药频率高达75.88%。核心药对为半夏-甘草、半夏-附子、附子-甘草、甘草-干姜、半夏-干姜等,其中半夏-附子的用药频率高达50.93%,占所有调研处方的大部分。另外核心药组主要为半夏-甘草-干姜、半夏-附子-甘草、半夏-甘草-黄芩、半夏-白术-甘草、半夏-党参-甘草等,其中半夏-附子-甘草的用药频率高达75.07%,占有很大比重。结论:"十八反"药物在临床应用中使用广泛,且同方配伍在临床上的应用范围也较广,说明"十八反"同用在临床确有存在,不是绝对的禁忌。更多还原

【Abstract】 Objective: To investigate the formation rule of ‘eighteen clashes’ in clinical applications based on data mining and analyze the compatible characteristics, in order to provide theoretical foundation and warning role for clinical application. Methods: The clinical prescriptions of top three traditional Chinese medicine hospitals in central China were gathered and the compatible characteristics of drugs was analyzed by using association rule mining. Results: The findings of ‘eighteen clashes’ clinical application showed that the core drugs of clinical compatibility in the hospital were liquorice root, pinellia tuber, prepared common monkshood branched root, dried ginger, largehead atractylodes rhizome, indian bread and so on, and the utilization frequency of pinellia tuber reached up to 75.88%. The core medicine suits were liquorice root-pinellia tuber, pinellia tuber-prepared common monkshood branched root, prepared common monkshood branched root-liquorice root, liquorice root-dried ginger and pinellia tuber-dried ginger, and utilization frequency of pinellia tuber-prepared common monkshood branched root reached up to 50.93%, and accounted for most of all the research prescriptions. The core component of drugs were pinellia tuber-liquorice root-dried ginger, pinellia tuber-prepared common monkshood branched root-liquorice root, pinellia tuber-liquorice root-baical skullcap root, pinellia tube-largehead atractylodes rhizome-liquorice root and pinellia tube-tangshen-liquorice root, and the utilization frequency of pinellia tuber-prepared common monkshood branched root-liquorice root reached up to 75.07%. Conclusion: Drugs in ‘eighteen clashes’ are widely used in clinical, and the applied range of compatibility of these drugs in prescriptions is also wide, which shows that the application of ‘eighteen clashes’ do exist in clinical, and it is not the ultimate taboo.更多还原