【摘要】 目的通过调控钛基体表面的结构和特性,提高惰性钛基体表面的生物活性,改善其医用植入效果。方法采用碱热处理方法在钛基体表面构建多级孔洞结构,对改性后钛片的表面形貌、成分、结构、亲疏水性进行表征,评价钛片表面对类骨磷灰石的诱导能力。结果碱热处理使钛表面形成了多孔网状结构,孔洞包括微米级孔和200~300 nm的纳米孔,孔隙间隔介于微米至几百纳米之间。碱热处理后的钛片表面形成了含有大量羟基的氧化物层,主要成分为金红石型Ti O2和碱性钛酸盐,具有极好的亲水性,接触角仅约为12°。碱热处理钛片表面的三维多孔结构对磷灰石的生长有很好的诱导作用,矿化7天后,类骨磷灰石便完全覆盖表面,14天后的矿化效果更好。结论纯钛表面通过碱热处理法构建微纳多孔结构后,具有良好的诱导羟基磷灰石形成的能力,对其生物活性有促进作用。更多还原

【Abstract】 Objective To improve the bioactivity of the titanium surface by regulating the surface morphology and properties so as to improve the effect for medical implantation. Methods Alkali heat treatment( AHT) was used to construct the hierarchical porous structure on the titanium surface. The surface morphology,structure,elements,and hydrophilicity of the treated titanium were characterized by a series of analytical tools. The biomimetic mineralization experiments were carried out to evaluate the hydroxyapatite formation on the treated surface in simulated body fluid( SBF). Results It was revealed that the hierarchical porous structure was formed after AHT,the holes included micron holes and 200 ~ 300 nm hole,the pore intervals varied from microns to hundreds of nanometers. An oxide layer containing a large number of hydroxyl groups was formed on the titanium surface after AHT. Hydrophilic of titanium surface after AHT was excellent,the contact angle was about 12. The alkaline titanate,as well as rutile Ti O2,was the main component of coating. The porous structure exhibited good apatite-inducing ability in SBF. Many bonelike apatite crystals were formed on AHT-titanium surface after 7 d immersion and the mineralization behavior exhibited even better after 14 d. Conclusion AHT-titanium with micro / nano pores exhibits the good inducibility for hydroxyapatite formation,which has a promotion effect on its biological activity.更多还原