【摘要】 目的探讨食管多通道腔内阻抗联合24小时p H监测观察胆囊排空功能对胃食管反流的影响。方法选择150例胃食管反流病患者,根据病症分为胆结石组、胆息肉组和胆囊正常组,利用脂餐刺激法计算胆囊排空率,利用MII-p H监测食管反流情况。最后评价GERD症状严重程度与胆囊排空功能的变化。结果胆结石组胆囊无论是空腹或进食脂质后大小都较其他两组大(P<0.05),而其胆囊排空率均比其余两组小(P<0.05),液体反流次数增加(P<0.05)。结论胆结石患者胆囊排空功能明显障碍;MII-p H可检测出GERD伴胆结石的患者反流加重、其成分更复杂;胆囊排空功能的异常会导致GERD反流情况的加重,但并不会明显改变患者的自觉症状。更多还原

【Abstract】 Objectives To investigate the influence of gallbladder emptying on gastroesophageal reflux disease(GERD) observed by esophageal multichannel intraluminal impedance. Methods 150 patients with GERD were divided into normal gallbladder, gallstones and gallbladder polyps group. Gallbladder emptying rate were measured by lipid metabolism stimuli method. The gastroesophageal reflux was monitored by MII-p H. The disease degree and gallbladder emptying were evaluated and analyzed. Results Both gallbladder volume and gallbladder emptying rate were higher in the GERD patients with gallstones than patients with normal gallbladder and gallbladder polyps. In addition, the frequency of liquid reflux in patients with gallstones was increased significantly. Conclusion Patients with gallbladder stones have significantly impaired gallbladder emptying. With the help of MII- p H, we find that patients with GERD and gallstones have a higher frequency of liquid reflux. The different degrees of gallbladder emptying have the same distribution of GERD symptoms.更多还原