【摘要】 目的:探讨重组人生长激素(r-h GH)联合应用支链氨基酸(BCAA)对肝硬化失代偿期患者肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的影响。方法:将82例肝硬化失代偿期患者随机分为治疗组42例和对照组40例。在相同保肝、支持治疗基础上,治疗组应用r-h GH 5 IU,每2天1次皮下注射,同时联用BCAA 250 ml,每天1次静脉滴注,连用20 d。对照组应用BCAA 250 ml,静脉滴注,每天1次,连用20 d。观察治疗前和治疗结束后第2天患者肝功能和TNF-α、IL-10水平变化情况。结果:2种治疗方法对患者肝功能指标、血清TNF-α和IL-10水平均有改善,但治疗组在纳差、下肢水肿等症状改善及丙氨酸氨基转移酶、白蛋白和血清TNF-α、IL-10水平改善方面均优于对照组(P<0.05~P<0.01)。结论:r-h GH联合BCAA在改善患者血清白蛋白和改善TNF-α、IL-10水平等方面优于单纯应用BCAA。更多还原

【Abstract】 Objective: To investigate the effects of recombinant human growth hormone( r-h GH) combined with branched chain amino acid( BCAA) on the levels of Tumor necrosis factor-α( TNF-α) and interleukins-10( IL-10) in patients with decompensated cirrhosis.Methods: Eighty-two patients with decompensated cirrhosis were randomly divided into the treatment group( 42 cases) and control group( 40 cases). The treatment group and control group were treated with 5 IU of r-h GH by subcutaneous injection 1 time two days combined with 250 ml of BCAA by intravenous drip once a day for 20 d and 250 ml of BCAA by intravenous drip once a day for 20 d based on protecting liver and support treatment,respectively. The liver function and levels of TNF-α and IL-10 in two groups were observed before and after treatment. Results: The liver function and levels of TNF-α and IL-10 in two groups were improved,the improvement of poor appetite,lower limbs edema,and the levels of alanine aminotransferase,albumin,TNF-α and IL-10 in treatment group were better than those in control group( P < 0. 05 to P < 0. 01). Conclusions: The effects of r-h GH combined with BCAA on the improvement of serum albumin,TNF-α and IL-10 levels are better than those of BCAA alone.更多还原