【摘要】 目的总结老年乳腺癌患者的临床特点,分析其对所采取治疗模式的影响。方法根据患者所处的年龄阶段(60~69岁和≥70岁)将178例接受治疗的老年乳腺癌患者分为A组(103例)和B组(75例)。分析两组患者所采取的治疗方式、疗效及不良反应等差异。结果 A组进行术后辅助化疗的患者比例明显高于B组,差异有统计学意义(P<0.05);年龄在60~69岁、雌性激素受体阴性及淋巴结转移阳性是术后采取辅助化疗的影响因素(P<0.05);A组的总有效率高于B组,但差异无统计学意义(P>0.05);两组均无严重不良反应发生。结论年龄在60~69岁的乳腺癌患者术后宜采取辅助化疗,≥70岁的乳腺癌患者可采取内分泌辅助治疗。更多还原

【Abstract】 Objective To summarize the clinical characteristics of elderly patients with breast cancer, and to evaluate the influences of adjuvant chemotherapy modality. Method A total of 178 cases of elderly breast cancer patients were included in this study, and were grouped by age(60-69 or ≥70) as group A(103 cases), and group B(75cases). The regimen, efficacy and adverse reactions of both groups were analyzed. Result There were more patients in group A who had underwent adjuvant chemotherapy compared with group B, and the difference was statistically significant(P<0.05); While age between 60-69, negative ER and positive lymph node metastasis were all significantly associated with postoperative adjuvant chemotherapy administration(P<0.05); Group A had higher yet insignificant overall response rate than that of group B(P>0.05); No serious adverse reactions were observed in either group. Con Conclusion For patients of 60-69 years old, adjuvant chemotherapy is applicable, and for those who are over 70 years old, adjuvant endocrine therapy is recommended.更多还原