Objective To optimize the ethanol extracting process of Pipa Qingfei granules. Methods The obtaining rate of extraction and the content of the berberine were taken as indexes for the ethanol extraction process. The ethanol extraction process of Pipa Qingfei granules was optimized by orthogonal design. Results The optimal conditions for the ethanol extraction of Pipa Qingfei granules were using 10 times of 70% ethanol solution,reflux three times,2 hours each time. Conclusion The optimal ethanol extracting me...