[Objective] Mesosulfuron-methyl safener on wheat was screened out to provide reference for application of mesosulfuron-methyl.[Method]Effects of three safener like isoxadifen-ethyl,cyclopropanesulfonamide and mefenpyr-diethyl on the herbicidal activity of mesosulfuron-methyl were studied. [Result]Wheat was sensitive for mesosulfuron-methyl,the height and fresh quality EC50 were 0. 20 and 0. 86 mg / L,respectively. Isoxadifen-ethyl and cyclopropanesulfonamide were unable to effectively relieve the phytotoxic...