【摘要】 目的探讨冠心病患者抗氧化标志物水平及其与中医证候分型的相关性。方法选择60名稳定型心绞痛(SAP)患者为SAP组,60名急性冠脉综合征(ACS)患者为ACS组,两组患者中医辨证分为心脉瘀阻证、痰浊内阻证、寒凝心脉证、心肾阴虚证、心肾阳虚证5型。另选60名健康体检者作为对照组,检测各组受试者血清超敏C反应蛋白(hs-CRP)和超氧化物歧化酶(SOD)水平,同时对不同中医证型的SAP、ACS患者hs-CRP、SOD水平进行相关性分析。结果 SAP组、ACS组的SOD水平较对照组明显下降,而hs-CRP水平较对照组明显升高,hs-CRP水平ACS组明显高于SAP组(P<0.05)。SAP组患者心肾阴虚证及心肾阳虚证患者hs-CRP水平明显低于心血瘀阻证(P<0.05),各证型与hs-CRP具有相关性,相关系数r=-0.825(P<0.01)。ACS组患者各证型与hs-CRP具有相关性,相关系数r=-0.436(P<0.01)。结论冠心病患者血清hs-CRP水平与中医证型有一定相关性,炎症反应可能影响中医证型的形成。更多还原

【Abstract】 Objective To explore the antioxidant marker level of coronary heart disease( CHD) patient and its correlation with traditional Chinese medicine( TCM) syndromes. Methods Sixty stable angina pectoris( SAP) patients were selected as SAP group and 60 acute coronary syndrome( ACS) patients were selected as ACS group. The TCM syndromes of patients in both groups were obstruction of heart meridian,phlegm obstruction,coldness blocking heart meridian,heart-kidney yin-deficiency,and heart-kidney yang-deficiency. In addition,60 healthy people were selected as the control group. The levels of high sensitivity C-reactive protein( hs-CRP) and superoxide dismutase( SOD)of participants were detected in each group. At the same time,a correlation analysis on hs-CRP and SOD of SAP and ACS patients with different TCM syndromes was performed. Results Comparing with the control group,the level of SOD was significantly decreased but the level of hs-CRP was significantly increased in SAP group and ACS group,especially the level of hs-CRP in ACS group( P < 0. 05). In SAP group,the level of hs-CRP in patients with heartkidney yin-deficiency syndrome and heart-kidney yang-deficiency syndrome was significantly lower than that in patients with obstruction of heart meridian syndrome( P < 0. 05). Each TCM syndrome in SAP group had correlation with hs-CRP,and the correlation coefficient was- 0. 825( P < 0. 01). Each TCM syndrome in ACS group also had correlation with hs-CRP and the correlation coefficient was- 0. 436( P < 0. 01). Conclusion Serum hs-CRP level of CHD patients has a certain correlation with TCM syndrome,and inflammatory reaction may affect the formation of TCM syndrome.更多还原