【摘要】 目的研究白芥子不同配比穴位贴敷对支气管哮喘患者免疫功能的影响。方法将90例支气管哮喘患者随机分为生白芥子组、生炒各半组、炒白芥子组,每组30例。生白芥子组贴敷药物为生白芥子、甘遂、延胡索、细辛(2∶2∶1∶1),生炒各半组为生白芥子、炒白芥子、甘遂、延胡索、细辛(1∶1∶2∶1∶1),炒白芥子组为炒白芥子、甘遂、延胡索、细辛(2∶2∶1∶1)。各组均取天突、膻中、定喘、风门、肺俞等穴于三伏天穴位贴敷,每伏贴敷1次,共3次。观察各组治疗后临床疗效、皮肤反应评分以及血清免疫球蛋白和噬酸粒细胞计数(EOS)的变化。结果生白芥子组临床治愈、显效、有效、无效病例分别为3、14、11、2例,生炒各半组分别为1、14、12、3例,炒白芥子组分别为1、10、11、8例,各组疗效比较差异无统计学意义(P>0.05)。治疗后生白芥子组、生炒各半组、炒白芥子组皮肤反应总积分依次降低,差异有统计学意义(P<0.05)。各组治疗前后血清免疫球蛋白及EOS差异均有统计学意义(P<0.05或P<0.01),治疗后炒白芥子组血清IgG较生白芥子组低(P<0.05)。结论白芥子不同配比穴位贴敷均可有效改善支气管哮喘患者症状及免疫功能,且随着生白芥子比例的增加患者皮肤反应逐渐加重,而皮肤反应的强弱程度对免疫功能的调节无显著影响。更多还原

【Abstract】 Objective To research the effects of acupoint application of Mustard Seeds with different proportions on the immune functions in patients with bronchial asthma. Methods Totally 90 cases of bronchial asthma were randomized into the raw Mustard Seeds group,half raw and half fried Mustard Seeds group and fried Mustard Seeds group,with 30 in each. In the raw Mustard Seeds group,raw Mustard Seeds,Gansui( Radix Kansui),Yanhusuo( Rhizoma Corydalis) and Xixin( Radix et Rhizoma Asari) were used at a ratio of 2 ∶ 2 ∶ 1 ∶ 1. In the half raw and half fried Mustard Seeds group,raw Mustard Seeds,fried Mustard Seeds,Gansui,Yanhusuo and Xixin were used at a ratio of 1 ∶ 1 ∶ 2 ∶ 1 ∶ 1. In the fried Mustard Seeds group,fried Mustard Seeds,Gansui,Yanhusuo and Xixin were used at a ratio of 2 ∶ 2 ∶ 1 ∶ 1. In each group,the acupoint application was conducted on Tianshu( CV22), Danzhong( CV17),Dingchuan( EX-B1),Fengmen( BL12) and Feishu( BL13) in the dog days( three periods forming the hottest periods of summer) once each period for three times. The efficacy,skin reactions,immunoglobullins and eosinophils( EOS) were observed after treatment. Results The cured,marked effective,effective and ineffective cases in the raw Mustard Seeds group were 3,14,11 and 2 respectively,while there were 1 cured,14 marked effective,12 effective and 3 ineffective in the half raw and half fried Mustard Seeds group,and there were 1 cured,10 marked effective,11 effective and 8 ineffective in the fried Mustard Seeds group,with no significant difference among groups( P > 0. 05). The total scores of skin reactions in the three groups,were significantly decreased after treatment( P < 0. 05). Differences in the inimmunoglobulins and EOS between before and after treatment were significant in all groups( P < 0. 05 or P < 0. 01). The serum IgG level in the fried Mustard Seeds group was significantly lower than that in the raw Mustard Seeds group( P < 0. 05). Conclusion The acupoint application of Mustard Seeds with different proportions can effectively relieve symptoms and improve immune functions in patients with bronchial asthma. The skin reactions are gradually increased as increasing the proportion of raw Mustard Seeds, but the degree of skin reaction has no significant effect on immune function.更多还原