【摘要】 目的观察通腑合剂治疗内镜逆行胰胆管造影(endoscopic retrograde choangiopancreatography,ERCP)术后胰腺炎(post-ERCP pancreatitis,PEP)的临床效果。方法将54例ERCP术后胰腺炎患者,随机分为常规治疗组(对照组)26例,通腑合剂治疗组(治疗组)28例。分别观察两组患者腹痛腹胀症状缓解时间、胃肠功能恢复时间及术后住院时间,并检测术前、术后12、48及96h血淀粉酶(AMY)、C反应蛋白(C-reactive protein,CRP)、内毒素(plasma endotoxin,LPS)、TNF-α及IL-6的变化。结果治疗组在腹痛腹胀缓解时间、胃肠功能恢复时间及术后住院时间上较对照组明显缩短,差异均有统计学意义(P<0.05)。术后48h和96h,治疗组血AMY及CRP恢复情况优于对照组,两组比较差异有统计学意义(P<0.05),而炎症因子LPS、TNF-α及IL-6则在术后96h,治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论通腑合剂治疗PEP有较好的临床效果,并能够缩短住院时间。更多还原

【Abstract】 Objective To observe the clinical efficacy of Tongfu Mixture(TM)for post-ERCP pancreatitis(PEP).Methods Totally 54 PEP patients were randomly assigned to the control group(treated by routine therapy,26 cases)and the TM treatment group(treated by TM,28 cases).Clinical indices including the alleviation time of abdominal pain/distention,gastrointestinal function recovery time,and the post-surgical length of stay were observed.Blood amylase(AMY),C-reactive protein(CRP),plasma endotoxin(PLS),TNF-α,and IL-6 were detected before surgery,12 h,48 h,and 96 h after surgery.Results The alleviation time of abdominal pain/distention,the gastrointestinal function recovery time,and the post-surgical length of stay were obviously shorter in the TM treatment group than those in the control group(P<0.05).The recovery of AMY and CRP were better in the TM treatment group than in the control group at post-operative 48 h and 96 h(P<0.05).The levels of LPS,TNF-α,and IL-6 were lower in the TM group than in the control group at post-operative 96 h(P<0.05).Conclusion TM showed better clinical efficacy and could significantly decrease the post-surgical length of stay.更多还原