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荧光原位杂交技术对恶性肿瘤细胞遗传学异常的检测

Detection of chromosomal abnormalities in malignant tumor by fluorescence insitu hybridization

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【Author】 HUANG Jun;DENG Ming-feng;CHEN Yong-ling;GUO Hua-xiong;CHEN Deng-feng;TANG Yuan-yan;HUANG Zhi-ping;Affiliated Jingzhou Hospital,Tongji Medicine College,Huazhong Science and Technology University,Department of Laboratory Medicine;Affiliated Jingzhou Hospital,Tongji Medicine College,Huazhong Science and Technology University,Department of Pathology;Affiliated Jingzhou Hospital,Tongji Medicine College,Huazhong Science and Technology University,Mammary Glands Section;Affiliated Jingzhou Hospital,Tongji Medicine College,Huazhong Science and Technology University,Department of Hematology;

【机构】华中科技大学同济医学院附属荆州医院检验医学部；华中科技大学同济医学院附属荆州医院病理科；华中科技大学同济医学院附属荆州医院乳腺外科；华中科技大学同济医学院附属荆州医院血液内科；

【摘要】目的评估荧光原位杂交(FISH)技术在乳腺癌、骨髓增生异常综合征(MDS)及慢性淋巴细胞白血病(CLL)等恶性肿瘤遗传学异常检测中的应用。方法选取乳腺癌患者55例,MDS患者48例和14例CLL患者,FISH法采用间期FISH。结果 55例乳腺癌患者中,HER2基因阳性16例(29.09%);48例MDS患者中27例(56.25%)阳性;14例CLL患者中9例(64.2%)阳性。结论 FISH能较快速检测恶性肿瘤患者遗传学异常的检出率,明显缩短检测时间。更多还原

【Abstract】 Objective:To study the sensitivity and specificity of fluorescence in situ hybridization(FISH)technique in the detection of malignant tumor. Methods:55 patients of breast cancer,48 patients of MDS and 14 patients of CLL were analyzed with FISH. Results:16(29.09%)of 55,27(56.25%)of 48 and 9(64.2%)of 14 were detected karyotype abnormalities by FISH. Conclusions:FISH could help the diagnosis and prognosis of malignant tumor.FISH is more sensitive and specific for detection of chromosome abnormalities.更多还原

【关键词】恶性肿瘤；荧光原位杂交；细胞遗传学；染色体异常；
【Key words】 Malignant tumor； Fluorescence in situ hybridization； Conventional cytogenetic analysis；

【文献出处】中国优生与遗传杂志 ,Chinese Journal of Birth Health & Heredity , 编辑部邮箱 ,2014年10期

【分类号】R730.43
【下载频次】121

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