【摘要】 目的探讨柳州地区非综合征型唇腭裂发生的环境危险因素,分析各因素的危险程度。方法采用1:1配对病例对照研究的方法,对广西柳州地区非综合征型唇腭裂患儿进行了环境影响因素的流行病学调查,采用配对资料χ2检验和单因素及多因素条件logistic回归分析筛选出与非综合征型唇腭裂易感性有关的环境因素,使用SPSS13.0进行统计分析。结果共调查非综合征型唇腭裂儿童与正常健康对照儿童178对。非综合征型唇腭裂患儿中单纯唇裂53例,唇裂合并腭裂79例,单纯腭裂46例。多因素分析提示居住在农村(OR=2.35)、母亲孕前6个月或孕早期接触宠物(OR=4.46)、母亲孕前6个月或孕早期被动吸烟(OR=2.20)、先兆流产(OR=20.8)、母亲慢性病史(OR=31.84)、母亲出生缺陷家族史(OR=11.14)、父亲职业有害物理因素接触史(OR=4.62)是非综合征型唇腭裂发生的危险因素,而母亲孕前6个月至孕早期补充叶酸(OR=0.30)、父亲文化程度高(OR=0.14)是非综合征型唇腭裂发生的保护因素。结论影响非综合征型唇腭裂发生的危险因素众多,根据研究结果采取有针对性的健康促进措施,提高孕前保健意识,对降低出生缺陷的发生率将起到积极作用。更多还原

【Abstract】 Objective:To explore the risk factors of susceptibility of non-syndromic cleft lip with or without cleft palate(NSCL/P)in Liuzhou city,Guangxi. Methods:A matched case-control study was performed to detect the information on maternal and paternal exposure before and during pregnancy of cases with non-syndromic cleft lip with or without cleft palate. McNemar test,univariate and multiple conditional logistic regression models were used to explore the association between environmental factors and the risk of NSCL/P. Results:In total,178 pairs subjects with NSCL/P children as case and healthy children as control were enrolled in this study. The cleft subtype ratio was 1:1.49 for cleft lip only with cleft lip and palate,and 1:0.87 for cleft lip only with cleft palate only. The results of multiple conditional logistic regression analysis indicated that living in rural area(OR=2.35),keeping pets before six months to the early stages of pregnancy(OR=4.46),passive smoking before six months to the early stages of pregnancy(OR=2.20),threatened abortion(OR=20.84),chronic disease history of mother(OR=31.84;),family history of birth defects(OR=11.14)and father’s occupational exposure to physical adverse factors of father(OR=4.62)were risk environment factors of NSCL/P. However,if supplement folic acid before six months to the early stages of pregnancy(OR=0.30)and the higher educational level of father(OR=0.14),the risk of NSCL/P of their offspring would decrease. Conclusion:The risk of the offspring developing NSCL/P is associated with many environment factors. Intended measures to prevent those risk factors could be effective in reducing the incidence of NSCL/P.更多还原