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胆碱能抗炎通路及其在中医药抗炎免疫研究中的进展
Progress in Research of Cholinergic Anti-inflammatory Pathway and Its Application in Traditional Chinese Medicinal Research
【摘要】 胆碱能抗炎通路(CAP)是近年发现的在神经免疫网络中发挥炎症调节作用的重要抗炎通路。α7烟碱型乙酰胆碱受体(α7 nAChR)是目前较明确的在CAP中发挥关键作用的受体,在免疫细胞上表达的α7 nAChR参与细胞增殖活化及炎症反应的调节,α7 nAChR已成为炎症相关性疾病的药物治疗靶标。本文综述CAP中α7 nAChR的作用机制及对免疫细胞的调节作用,并阐述中医药通过CAP发挥抗炎作用的研究现状。
【Abstract】 Nicotinic acetylcholine receptor alpha7(α7 n ACh R)is a receptor which participates in the activation of cell proliferation and the regulation of inflammatory response. It is confirmed that α7 n ACh R plays an important role in the cholinergic anti-inflammatory pathway(CAP),and has become the therapeutic target of inflammation-related diseases.This paper reviews the mechanism of α7 n ACh R in CAP and the regulatory effect ofα7 n ACh R on immune cells,and clarified that CAP may be one of the anti-inflammatory pathway of traditional Chinese medicine.
- 【文献出处】 中药新药与临床药理 ,Traditional Chinese Drug Research and Clinical Pharmacology , 编辑部邮箱 ,2014年06期
- 【分类号】R285.5
- 【被引频次】8
- 【下载频次】492