【摘要】 目的:观察滋阴润燥生津汤联合硫酸羟化氯喹治疗干燥综合征的临床疗效。方法:将104例原发性干燥综合征患者随机分为三组。A组52例,应用滋阴润燥生津汤联合硫酸羟化氯喹片治疗;B组26例,应用硫酸羟化氯喹片治疗;C组26例,采用人工唾液、人工泪液对症治疗。比较三组患者治疗前后在口干眼干症状评分、唾液流率、Schirmer实验、血沉(ESR)及IgG等方面的疗效。结果:三组患者治疗前实验室指标和临床症状比较,差异无统计学意义(P>0.05),治疗后A组、B组患者口干眼干、唾液流率、Schirmer实验、ESR及IgG等指标较治疗前有明显改善(P<0.05),且A组优于B组,C组治疗后较治疗前各项指标差异无统计学意义(P>0.05)。结论:滋阴润燥生津汤联合硫酸羟化氯喹治疗干燥综合征,缓解口干、眼干症状效果显著,有良好的治疗效果。更多还原

【Abstract】 Objective: To observe the effect of traditional Chinese medicine of Ziyin Runzao Shengjin decoction and Hydroxychloroquine on Sjogren’s syndrome. Methods: 104 patients of Sjogren’s syndrome were randomly divided into three groups. Group A,including 52 patients,was treated with Chinese medicine of Ziyin Runzao Shengjin decoction and Hydroxychloroquine for one month. Group B,including 26 patients,was treated only by Hydroxychloroquine. Group C,including 26 patients,was aimed at relieving symptom. The scores for dry mouth and dry eyes,the efficacy on salivary flow rate,Schirmer test,erythrocyte sedimentation rate( ESR) and IgG,and so on were compared among the three groups before and after treatment. Results: There was no significant difference in the laboratory parameters and clinical symptoms among the three groups before treatment. After treatment obvious improvement of the scores for dry mouth,the salivary flow rate,Schirmer test,ESR,and IgG was shown in group A and group B( P < 0. 05),Besides,the optimal effect was shown in group A. In group C there was no statistical difference before and after treatment( P > 0. 05). Conclusion: Traditional Chinese medicine of Ziyin Runzao Shengjin decoction and Hydroxychloroquine can relieve xerosis and xerostomia effectively and has a positive effect on primary Sjogren’s syndrome.更多还原