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补肾通督胶囊对胶原诱导关节炎大鼠的免疫调控作用
Immunoregulative Effect of Bushen Tongdu Capsule on Arthritis Rats Induced by Collagen
【摘要】 目的:研究补肾通督胶囊对CIA大鼠的免疫调控作用。方法:将大鼠分为正常对照组、模型组、补肾通督胶囊(BS)低剂量组、中剂量组、高剂量组和雷公藤组,接受相应治疗。结果:BS对脾脏、外周血淋巴细胞有调控作用,对血清IL6和Ⅱ型胶原蛋白抗体的水平有抑制作用。结论:补肾通督胶囊对外周血淋巴细胞的调控作用效果显著。
【Abstract】 Objective: To investigate the effect of Bushen Tongdu capsules on arthritis rats induced by collagen. Methods:Rats were randomly assigned into six groups,normal control( C),model( M),low dose of BS( BSL),medium dose( BSM),high dose( BSH),tripterygium glycosides( TG) groups and they were treated. Results: Bushen Tongdu capsules could relieve hyperplasia of spleen white pulp,modulate peripheral lymphocytes,IL- 6 and coll- Ⅱ antibody.Conclusion: Bushen Tongdu capsules are effective on modulation of peripheral lymphocyte functions.
【关键词】 补肾通督胶囊;
胶原诱导关节炎;
CD4+CD25+Treg细胞;
IL-6;
Ⅱ型胶原抗体;
【Key words】 Bushen Tongdu capsules; Arthritis induced by collagen; CD4+CD25+Treg cell; IL-6; Coll-Ⅱ antibody;
【Key words】 Bushen Tongdu capsules; Arthritis induced by collagen; CD4+CD25+Treg cell; IL-6; Coll-Ⅱ antibody;
【基金】 太原市科技项目(编号:12016922)
- 【文献出处】 中医药学报 ,Acta Chinese Medicine and Pharmacology , 编辑部邮箱 ,2014年04期
- 【分类号】R285.5
- 【下载频次】71