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补肾通督胶囊对胶原诱导关节炎大鼠的免疫调控作用

Immunoregulative Effect of Bushen Tongdu Capsule on Arthritis Rats Induced by Collagen

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【作者】 林琳王英旭朱阳春周晓莉侯丽萍

【Author】 LIN Lin;WANG Ying-xu;ZHU Yang-chun;ZHOU Xiao-li;HOU Li-ping;Beijing University of Chinese Medicine;Taiyuan Rheumatoid Hospital;Shanxi Hospital of Traditional Chinese Medicine;

【机构】 北京中医药大学太原市类风湿病医院山西省中医院

【摘要】 目的:研究补肾通督胶囊对CIA大鼠的免疫调控作用。方法:将大鼠分为正常对照组、模型组、补肾通督胶囊(BS)低剂量组、中剂量组、高剂量组和雷公藤组,接受相应治疗。结果:BS对脾脏、外周血淋巴细胞有调控作用,对血清IL6和Ⅱ型胶原蛋白抗体的水平有抑制作用。结论:补肾通督胶囊对外周血淋巴细胞的调控作用效果显著。

【Abstract】 Objective: To investigate the effect of Bushen Tongdu capsules on arthritis rats induced by collagen. Methods:Rats were randomly assigned into six groups,normal control( C),model( M),low dose of BS( BSL),medium dose( BSM),high dose( BSH),tripterygium glycosides( TG) groups and they were treated. Results: Bushen Tongdu capsules could relieve hyperplasia of spleen white pulp,modulate peripheral lymphocytes,IL- 6 and coll- Ⅱ antibody.Conclusion: Bushen Tongdu capsules are effective on modulation of peripheral lymphocyte functions.

【基金】 太原市科技项目(编号:12016922)
  • 【文献出处】 中医药学报 ,Acta Chinese Medicine and Pharmacology , 编辑部邮箱 ,2014年04期
  • 【分类号】R285.5
  • 【下载频次】71
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