【摘要】 目的:探讨狭叶荨麻提取物的抗炎镇痛药理作用。方法:观察狭叶荨麻提取物对二甲苯所致小鼠耳肿胀模型、对蛋清所致大鼠足肿胀模型、对醋酸所致小鼠扭体反应模型以及对小鼠热板镇痛模型实验的影响。结果:与模型组比较,狭叶荨麻乙酸乙酯提取物组能显著抑制二甲苯所致小鼠耳肿胀、蛋清所致大鼠足肿胀,并对醋酸所致小鼠扭体反应以及对热板小鼠表现出显著的镇痛作用。结论:狭叶荨麻乙酸乙酯提取物具有显著的抗炎镇痛作用。更多还原

【Abstract】 Objective: To explore the effects of anti- inflammation and analgesia of extracts from Urtica angustifolia.Methods: Research of anti- inflammatory effect were done through dimethylbenzene- induced ear swelling models of mice,egg white- induced paw edema models of rats and research of analgesic effect were done through acetic acid- induced writhing reaction on mice and hot plate- induced pain on mice. Results: Above experiments showed that ethyl acetate extract group could significantly restrain dimethylbenzene- induced ear swelling of mice and egg white- induced paw edema of rats compare with model group. At the same time,ethyl acetate extract had a significantly analgesic effect on acetic acid- induced writhing reaction on mice and hot plate- induced pain on mice. Conclusion: This study demonstrates that ethyl acetate extract from Urtica angustifolia has a remarkably anti- inflammatory and analgesic effect.更多还原