【摘要】 目的:揭示扶正抑瘤法治疗恶性肿瘤的中药用药策略与机理。方法:选取扶正抑瘤法治疗恶性肿瘤的文献,寻找有关药物对恶性肿瘤的用药策略与机理。结果:扶正抑瘤法用药策略:①扶正培本:要根据患者气虚、血虚、阴虚、阳虚、脾虚、肾虚、肺虚、心虚等不同而相应选择补气、补血、补阴、补阳、健脾、补肾、补肺、补心等有抗肿瘤活性的中药;②抑瘤抗癌:要根据患者气滞血瘀、痰湿凝聚、热毒内蕴等不同而相应选择理气行滞、活血化瘀、化痰祛湿、软坚散结、清热解毒、以毒攻毒等有抗肿瘤活性的中药;③扶正与抑瘤要权衡病情轻重缓急;④配合放化疗要重视益气养阴,补气生血,补益脾肾;⑤处方用药追求循证医学证据支持。扶正抑瘤法抗恶性肿瘤的机理:直接细胞毒作用;抑制肿瘤血管生成;抑制细胞外基质的降解;提高机体免疫功能;逆转肿瘤细胞多药耐药;对化疗的减毒增效作用;诱导肿瘤细胞凋亡;诱导肿瘤细胞分化;抑制肿瘤细胞转移等。结论:扶正抑瘤法能早期抑杀肿瘤,减毒增效;中期推迟病情进展,控制转移;后期提高生存质量,延长生存期。更多还原

【Abstract】 Objective:This study aims to reveal medicine administration strategy and mechanism of strengthening body resistance and inhibiting tumor method(SBRITM) for treating malignant tumor.Method:Select the literatures of malignant tumors treated by SBRITM,and look for medicine administration strategy and mechanism of SBRITM for treating malignant tumor.Results:SBRITM Medicine administration strategy:①Strengthening body resistance and consolidating the constitution(SBRCC):according to deficiency of Qi,blood,Yin,Yang,spleen,kidney,lung and heart,select TCM medicine with anti-tumor activity in the categories of Tonifying Qi,blood,Yin,Yang,spleen,kidney,lung,heart and so on respectively;②Inhibiting tumor:according to blood stasis,phlegm coagulation,heat toxin,select TCM medicine with anti-tumor activity in the categories of regulating Qi-flowing for activating stagnancy,promoting blood circulation for removing blood stasis,dispelling phlegm and eliminating dampness,resolving hard lump,clearing away heat and toxic material,using poisons as antidotes and so on accordingly;③SBRITM need weigh the order of priorities:④Tonifying Qi and Yin,nourishing Qi and blood,invigorating spleen and kidney with chemotherapy and radiotherapy.⑤Prescription should support evidence based medicine.SBRITM mechanisms:direct cytotoxicity;inhibition of tumor angiogenesis;inhibition of extracellular matrix degradation;improve immune function;reversal of multidrug resistance of tumor cells;attenuated chemotherapy and synergies;inducing apoptosis;inducing tumor cell differentiation;inhibit tumor cell metastasis.Conclusion:SBRITM can suppress and kill tumors,induce synergism and reduce side effects of chemotherapy or radiotherapy at early stage;SBRITM can slow disease progression,control transfers at mid-term stage;SBRITM can improve the quality of life and prolong survival at later stage.更多还原