【摘要】 目的探讨肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)、血清骨保护素(OPG)与2型糖尿病合并冠心病的关系。方法入选健康个体(对照组)和2型糖尿病合并冠心病患者(冠心病组)各30例,用ELISA方法测定TNF-α、IL-1β、OPG,生化法测定血糖及糖化血红蛋白,并观察组间各指标的变化及相互关系。结果 2型糖尿病合并冠心病组血清空腹血糖、糖化血红蛋白、OPG明显高于对照组(P均<0.01),TNF-α、IL-1β高于对照组(P均<0.05)。Spearman相关分析显示,OPG与TNF-α、IL-1β呈显著正相关(P均<0.01)。结论血糖、糖化血红蛋白、TNF-α、IL-1β、OPG在2型糖尿病合并冠心病患者中明显增高,OPG与TNF-α、IL-1β改变有关。更多还原

【Abstract】 Objective To investigate the relationship between tumor necrosis factor-α( TNF-α),Interleukin-1β( IL-1β),Osteoprotegerin( OPG) and type 2 diabetes mellitus( T2DM) with coronary artery disease( CAD).Methods Thirty healthy individuals( control group),and 30 T2DM patients with CAD( T2DM + CAD) group were selected.ELISA was used for determination of TNF-α,IL-1β and OPG,biochemistry method for blood glucose and glycosylated hemoglobin,and the data in all groups and the relationship between the factors was observed.Results Fasting blood-glucose,glycosylated hemoglobin,OPG in T2DM group were obviously higher than those in control group( P < 0.01),and TNF-α,IL-1β in T2DM group were obviously higher than those in control group( P < 0.05).Spearman correlation analysis showed that the positive correlation existed between OPG and TNF-α,IL-1β( P < 0.01).Conclusion The levels of blood glucose,glycosylated hemoglobin,TNF-α,IL-1β and OPG in T2MD group increase obviously.The level of OPG was related to the changes of TNF-α and IL-1β.更多还原