【摘要】 目的观察乳癌基因1(BRCA1)在鼻咽癌中的表达水平并分析其表达水平与预后的关系。方法采用免疫组化S-P法检测100例患者鼻咽癌组织中BRCA1蛋白的表达水平,阳性细胞计数≥50%定为BRCA1高表达组;<50%及不表达者定为BRCA1低表达组。应用χ2检验对BRCA1表达水平与临床资料进行关联性分析。结果 100例患者中13例失访,BRCA1高表达者37例(42.5%),低表达者50例(57.5%);BRCA1表达与患者的临床分期(P=0.383)、原发灶退缩情况(P=0.434)、肿瘤发生远处转移(P=0.055)无明显关联性,高表达组生存率稍高于低表达组,但差异无统计学意义(P>0.05)。结论鼻咽癌组织中BRCA1蛋白的表达与临床分期和原发灶退缩程度无关,但BRCA1低表达者更易出现远处转移的趋势。更多还原

【Abstract】 Objective To investigate the protein expression of Breast cancer1( BRCA1) in nasopharyngeal carcinoma( NPC) and to analyze the relationship of BRCA1 expression with the prognosis.Methods The expression of BRCA1 proteins in the tissue of nasopharyngeal carcinoma in 100 patients with NPC was detected by immunohistochemistry.The high BRCA1 expression group included patients whose biopsy specimens showed at least 50% immunopositive tumor cells; The low BRCA1 expression group included patients whose biopsy specimens showed less than 50% immunopositive tumor cells,including negative expression.The correlations between protein expression and clinical data were assessed using the chi-square test.Results Thirteen patients failed to be followed-up.And in the rest 87 patients,the high BRCA1 expression group and low BRCA1 expression group included 37 patients( 42.5%) and 50 patients( 57.5%) respectively.No significant differences were found between the expression of BRCA1 proteins and TNM stage( P = 0.383),tumor regression( P = 0.434),or distant metastasis( P = 0.055).The survival rate in the high BRCA1 expression group was higher than that in the low BRCA1 expression group,but there was no statistically significant differences between two groups( P > 0.05).Conclusion There was no significant correlation between the expression level of BRCA1 and TNM stage and tumor regression in nasopharyngeal carcinoma.However,the low expression of BRCA1 were more prone to metastasis tendency.更多还原