【摘要】 目的探讨中国女性子宫颈癌在1989至2008年的发病和死亡趋势,为制定和评价我国子宫颈癌防治策略提供参考依据。方法根据1989至2008年全国肿瘤登记中心的发病和死亡数据,计算城市和农村子宫颈癌的发病和死亡粗率,以及标准化人口年龄调整的发病率和死亡率(中国人口标化率和世界人口标化率)。采用Joinpoint软件估算年度变化百分比,分析1989至2008年子宫颈癌发病率和死亡率的变化趋势。结果全国子宫颈癌粗发病率由1989至1990年的3.06/10万上升到2007至2008年的11.87/10万,城市肿瘤登记地区由4.96/10万上升到11.98/10万,农村地区由2.39/10万上升到11.77/10万。全国子宫颈癌的粗死亡率由1989至1990年的2.19/10万上升到2007至2008年的3.20/10万,城市肿瘤登记地区由3.21/10万到2.56/10万,农村地区由1.82/10万上升到3.75/10万。1989至2008年子宫颈癌的粗发病率无论城市还是农村总体均呈上升趋势,分别在1997年和1999年后以平均每年14.4%和22.5%的速度递增;世界人口年龄标化后,城市地区增速变化不大,农村地区小幅降低。虽然全国子宫颈癌的粗死亡率和世界人口标化率在1989至2008年总体无变化,但在1999年后粗死亡率平均每年上升8.1%;城市地区的粗死亡率和世界人口标化率在2001年后均以平均每年7.3%的速度递增;而农村地区的粗死亡率在1989至2008年平均每年上升3.9%,世界人口标化率无变化。结论近十几年来我国子宫颈癌的发病率和死亡率逐年升高,迫切需要建立适合我国国情的子宫颈癌筛查和疫苗相结合的综合防治体系,从而有效降低子宫颈癌的疾病负担。更多还原

【Abstract】 Objective To evaluate the trend of cervical cancer incidence and mortality rates during 1989-2008 in Chinese women,so as to inform the development of relevant policies and strategies in China. Methods The incidence and mortality rates of cervical cancer during 1989-2008 in urban and rural areas werecalculated based on the data from the National Cancer Registry Database. Age-standardized rates were calculated using the Chinese population of 1982 and World Segi’s population of 1985. Joinpoint regression analysis was performed to obtain annual percentage changes( APC) so as to assess the trend of incidence and mortality rates over the period from 1989 to 2008. Results The crude incidence rate of cervical cancer in Chinese women increased from 3. 06 /105in 1989-1990 to 11. 87 /105in 2007-2008( from 4. 96 /105to 11. 98 /105in urban registration areas and from 2. 39 /105to 11. 77 /105in rural registration areas). The crude mortality rate slightly increased from 2. 19 /105in 1989-1990 to 3. 20 /105in 2007-2008( from 3. 21 /105to 2. 56 /105in urban registration areas and from 1. 82 /105to 3. 75 /105in rural registration areas). Generally,the upward trends of crude incidence rates were shown over the year 1989-2008,with an APC of 14. 4% after 1997 in urban areas and 22. 5% after 1999 in rural areas. After age standardization of world population,the APC of incidence rates in recent decade in urban areas remained stable,and the one in rural areas slightly decreased. Although the overall crude and world agestandardized mortality rates had no significant changes during 1989-2008,the crude mortality rates increased by 8. 1% annually after 1999. The upward trends were also shown for crude and world age-standardized mortality rates in urban areas after 2001 with an APC of 7. 3%. The crude mortality rates in rural areas increased by 3. 9% annually during 1989-2008,but no significant change was found after age standardization. Conclusions Over the last decade,the cervical cancer incidence and mortality rates ascended by year in China. It is particularly urgent to establish a comprehensive prevention and control system that combines cervical cancer screening and human papillomavirus vaccination,so as to reduce the burden of cervical cancer in Chinese women.更多还原