【摘要】 目的观察自拟清热宣肺汤加减直肠滴注应用于呼吸机相关性肺炎重症患的疗效。方法选择本院ICU病房呼吸机相关性肺炎重症患者56例,按数字表法随机分为对照组与观察组各28例,对照组采用常规治疗,包括干扰素皮下注射、盐酸左氧氟沙星静滴;观察组在此基础上加用自拟清热宣肺汤加减直肠滴注,两组均用药10 d为1个疗程,观察两组治疗效果。结果观察组总有效率92.86%,对照组为75.00%。治疗后观察组中性细胞数、白细胞、淋巴细胞比率等指标均有明显降低(P<0.05),观察组降低程度显著优于对照组(P<0.05)。结论呼吸机相关性肺炎重症患者采用自拟清热宣肺汤加减直肠滴注可以有效抑制炎症反应,有效抗菌。更多还原

【Abstract】 Objective: To observe the clinical effect of Qingrexuanfei Decoction on ICU patients with ventilatorassociated pneumonia. Methods: 56 cases were randomly divided into control group(n=28) and observation group(n=28). Conventional treatments including interferon gamma subcutaneous injection were used in control group. Qingrexuanfei Decoction based on the conventional therapy was added in observation group. After 10 days, the clinical effects of two groups were observed and compared. Results: The total effective rate of observation group was 92.86% that was significantly higher than 75.00% of control group(P < 0.05). After treatment,neutrophil number,white blood cell,and lymphocyte ratio were remarkably decreased(P < 0.05) in observation group. Moreover,the decline rates in observation group were sharper than those in control group(P < 0.05). Conclusion: Inflammatory reaction of ICU patients with ventilator-associated pneumonia could be effectively inhibited by rectal infusion of Qingrexuanfei Decoction. It has antibacterial effect and is worthy of clinical promotion.更多还原