【摘要】 目的观察抗骨松汤对去卵巢后大鼠血清中胰岛素生长因子-1(IGF-1)、白细胞介素-1(IL-1)及子宫内膜的影响,探寻抗骨松汤防治绝经后骨质疏松症作用机制。方法将7月龄Wistar雌性大鼠40只,随机分为假手术组、模型组、尼尔雌醇组和抗骨松汤4组,用去大鼠双侧卵巢复制绝经后骨质疏松症的模型,术后10周给予相应药物灌胃,12周后检测IGF-1和IL-1水平,测量子宫内膜厚度。结果模型组IGF-1下降,IL-1上升;尼尔雌醇组和抗骨松汤IGF-1水平升高,IL-1水平降低,且与假手术组比较差异无统计学意义(P>0.05)。模型组子宫内膜萎缩变薄,尼尔雌醇组子宫内膜增厚,抗骨松汤组与假手术组比较差异无统计学意义(P>0.05)。结论抗骨松汤组能升高IGF-1,降低IL-1,避免对子宫内膜过度刺激。更多还原

【Abstract】 Objective: To observe the effect of anti-osteoporosis decoction on insulin growth factor-1(IGF-1),interleukin-1(IL-1) in ovariectomized rat serum and on endometrium and investigate the mechanism of prevention and treatment of postmenopausal osteoporosis. Methods: 40 female Wistar rats of 7 months old were randomly divided into sham operation group,model group,Neal female alcohol group and anti-osteoporosis decoction group. Ovariectomized rats were used to replicate the model of postmenopausal osteoporosis rats which were given corresponding drugs to fill the stomach 10 weeks after operation. IGF-1 and IL-1 were detected and the thickness of endometrium was measured 12 weeks later. Results: IGF-1 decreased while IL-1 increased in model group. IGF-1 increased while IL-1 decreased in Neal estradiol group and in anti-osteoporosis decoction. Compared with sham operation group,there was no statistical difference. Endometrial atrophy appeared in model group while endometrium thickened in Neal female alcohol group. Anti osteoporosis soup group and sham operation group had no statistical difference. Conclusion: Anti-osteoporosis decoction group could increase IGF-1 and reduce IL-1 and can prevent excessive stimulation on endometrium.更多还原