【摘要】 目的探讨重症肌无力患者(MG)术后发生肌无力危象(MC)的危险因素,为早期预防和诊断MC提供依据。方法采用病例对照研究方法,将确诊的198例MG患者术后依据是否发生MC分为病例组和对照组,采用单因素和多因素logistic回归分析MC发病的危险因素。结果 MC的发病率为16.2%;多因素logistic回归分析结果显示,肌无力发生的危险因素有5个:胸腺瘤(OR=3.658)、Osseman分型(OR=2.570)、肌无力发生史(OR=4.212)、术前MC(OR=4.998)及抗胆碱酯酶药物不足(OR=2.641)。结论 MG患者术后发生MC的发病率较高,影响MC发病的独立危险因素较多且机制复杂,应针对这些高危因素进行早预防和诊断。更多还原

【Abstract】 [Objective]To explore the risk factors of postoperative myasthenic crisis( MC) in patients with myasthenia gravis( MG),provide basis for early preventing and diagnosing MC.[Methods]With case-control study method,196 cases of MG were divided into case group and control group according to whether or not MC occured. And the risk factors of MC were analyzed by single factor and multi- factor Logistic Regression analysis. [Results]The incidence of MC was 16. 2%. The result of the multi-factor logistic regression analysis showed that the risk factors were thymoma( OR = 3. 658),Osseman typing( OR = 2. 570),history of myasthenia( OR = 4. 212),preoperative MC( OR = 4. 998) and not enough anticholinesterase drug( OR = 2. 641). [Conclusion] The incidence of MC in MG patients after operation is high. There are many independent risk factors and complicated mechanism affecting the incidence of MC,we should take early prevention and diagnosis against these high risk factors.更多还原