【摘要】 目的:研究复方降糖滴丸对大鼠的长期毒性。方法:采用SD大鼠长期灌胃不同剂量复方降糖滴丸10.41、20.82、41.65 g/kg。给药3个月后处死一半动物,其余停药恢复观察2周后处死;以大鼠的血常规、血生化、脏器指数、主要脏器组织病理学为检测指标,观察复方降糖滴丸大鼠长期毒性。结果:大鼠给药3个月及恢复期间,总体体征与空白组相比无明显差异,并无中毒死亡;血常规和血生化检测结果显示,与空白组相比,除高剂量TG、AST有差异,总体指标无明显变化;组织病理学检查结果显示,与空白组相比,除部分给药组肺和肝脏有病理变化外,其余脏器无明显变化。结论:复方降糖滴丸无明显不良反应,口服安全,安全性良好。更多还原

【Abstract】 Objective: This study was planned to assess compound hypoglycemic pill safety in rats. Methods: The long- term toxicity test used SD rats which were treated with compound hypoglycemic pill at doses of 10. 41、20. 82、41. 65 g /kg( ig). Half rats were killed after 3 months,and the remaining recovered 2 weeks with withdrawing pills. The blood routine indexes,blood biochemical indexes,organ coefficient and histopathology of major organs of rats were examined for evaluation of toxicity. Results: No rats died and no serious toxic reactions in the long- term toxicity experiment. The detection of blood routine indexes and blood biochemical indexes showed that few significant changed between the NC and compound hypoglycemic pill groups,except the indexes of TG and AST in the 41. 65 g /kg. Conclusion: It is very safe that mice and rats take compound hypoglycemic pill in the dosage of test and there is no harm for body. It’s safety.更多还原