【摘要】 目的:通过对鼻咽癌高发区大样本人群鼻咽癌筛查两种抗体水平分析,为鼻咽癌高发区的防治策略提供科学依据。方法:应用ELISA法检测EBNA1-IgA和EBVCA-IgA抗体,对两种EB病毒抗在性别、年龄的阳性率和可疑阳性率的分布特征进行研究。结果:筛查人群EBNA1-IgA抗体阳性率和可疑阳性率分别为9.27%(778/8395)、12.54%(1053/8395),EBVCA-IgA抗体阳性率和可疑阳性率分别为11.79%(990/8395)、13.60%(1142/8395)。男性EBNA1-IgA抗体阳性率为10.53%,高于女性的8.01%,差异有统计学意义(P<0.05);男、女性EBVCA-IgA抗体阳性率分别为11.77%和11.82%,两组比较差异无统计学意义(P>0.05)。结论:EBNA1-IgA抗体(45~60岁年龄段)分布男性高于女性。VCA-IgA抗体阳性率无显著差异,筛查人群的EBNA1-IgA和VCA/IgA抗体阳性率和可疑阳性率随着年龄增长逐渐上升。提示须加强对此年龄段人群的EB病毒感染的定期筛查,可提高鼻咽癌的早诊率。更多还原

【Abstract】 Objective:To analyze the high incidence large population-based screening nasopharyngeal carcinoma(NPC) two kinds of antibody level,to provide scientific basis for prevention and control of high incidence of nasopharyngeal carcinoma strategies.Method:EBNA1 IgA and EBVCA IgA antibodies were detected by ELISA method,resistance of two kinds of EB virus in gender,age,the positive rate and the distribution features of the suspicious positive rate were studied.Result:The positive rate of screening population EBNA1-IgA antibody positive rates were 9.27%(778/8395),12.54%(1053/8395),EBVCA-IgA antibody positive rate and the positive rate was 11.79% suspicious(990/8395),13.60%(1142/8395) respectively.Men EBNA1-IgA antibody positive rate was 10.53%,it was significantly higher than 8.01% of women,the difference was statistically significant(P<0.05);Male and female EBVCA-IgA antibody positive rate were 11.77% and 11.82% respectively,the difference was no statistically significant(P>0.05).Conclusion:EBNA1-IgA antibodies(45-60 years of age) distribution in men than women.VCA-IgA antibody positive rate is no significant difference,the results show that people EBNA1/IgA and VCA/IgA antibody positive rate and suspicious positive rate increase with age.Tip must strengthen this ages of regular screening of EB virus infection,can improve the rate of early detection of nasopharyngeal carcinoma.更多还原