【摘要】 目的:了解郑州市二七区内8家医院的出生缺陷发生率,分析其影响因素,为制定适宜的干预策略和措施提供科学依据。方法:对郑州市二七区内8家医院1年内分娩的围产儿进行监测,并对其中117例出生缺陷儿进行1:2病例对照,采用单因素、多因素logistic回归模型分析出生缺陷的影响因素。结果:出生缺陷的发生率为183.41/万。多因素logistic逐步回归分析结果显示:无孕前检查、孕早期偏食、孕期接触化学制剂、既往分娩缺陷儿史、孕期不良情绪、孕期患病史是发生出生缺陷的危险因素。结论:要普遍宣传健康知识,避免出生缺陷的危险因素,作好围产期保健工作,预防和减少出生缺陷的发生,提高我国出生人口素质。更多还原

【Abstract】 Objective: To investigate the incidence of birth defects(BD)in eight hospitals of Erqi district in Zhengzhou, to explore correlation factors of BD, and to provide scientific basis for developing appropriate intervention strategies and measures for BD. Method: All new born were monitored and a 1:2 case-control study for BD was performed in 117 babies with BD in eight hospitals of Erqi district in Zhengzhou during one year. Simple and multivariate logistic regression models were used to identify the correlates of BD. Result: The incidence of birth defects was 183.41 per 10 000 live births. In multiple factors analysis, backward stepwise regression was used to fit the main effects of equation. The experience without progestational examination, partiality for a particular kind of food during early pregnancy, contacted chemical agent, maternal history of birth defects, unhealthy emotion, diseases history during pregnancy were risk factors of BD. Conclusion: We should propagandize health knowledge widely in the crowd to avoid risk factors of BD, and do well in health care of perinatal period to prevent and reduce the incidence of birth defects, so as to improve the quality of the population born in China.更多还原