【Objective】 To evaluate the effects of sepsis at different stage on pharmacodynamics of cisAtracurium. 【Methods】 45 patient were randomly divided into three groups: control group: 15 patients were in good general condition, no symptoms of infection, ASA grade of Ⅰ ~ Ⅱ, who underwent cholecystectomy;SIRS group: 12 patients were with gastrointestinal perforation and in systemic inflammatory response syndrome phase of sepsis; severe sepsis group: 9 patients were with gastrointestinal perforation and in severe ...