Objective To investigate the feasibility of tissue engineered periosteum(TEP) constructed by porcine small intestinal submucosa(SIS) and bone marrow mesenchymal stem cells(BMSCs) of rabbit to repair the large irregular bone defects in allogenic rabbits.Methods The BMSCs were cultivated from the bone marrow of New Zealand white rabbits(aged,2 weeks-1 month).SIS was fabricated by porcine proximal jejunum.The TEP constructed by SIS scaffold and BMSCs was prepared in vitro.Eighteen 6-month-old New Zealand white...