【摘要】 目的分析天台县妇女宫颈人乳头状瘤病毒(HPV)感染情况及亚型分布。方法采用HPV-PCR反向斑点杂交技术对宫颈脱落细胞标本进行HPV分型检测。结果 3 253例样本中,检出HPV阳性者781例,阳性率为24.01%,检出22种亚型,其中高危型、低危型和高低危合并感染分别为539例(69.01%)、129例(16.52%)和113例(14.47%)。HPV单一亚型感染546例(69.91%),多重感染235例(30.09%)。不同年龄组HPV感染高峰在≤20岁、51岁~和>60岁,感染率分别为37.50%、31.39%和26.84%。主要感染亚型为HPV16、HPV52、HPV58、HPV81、HPV33、HPV18。结论女性HPV感染呈普遍化趋势,各年龄组检测阳性率差异有统计学意义(P<0.05),对≤20岁及>50岁的妇女应予以重视,对阳性患者要定期随访,对育龄妇女进行HPV基因分型检测有利于宫颈癌的早期预警和治疗。更多还原

【Abstract】 Objective To investigate the status of human papilloma virus(HPV) infection and subtype distribution of HPV among women in Tiantai county.Methods The samples of cervical exfoliated cells were detected by human papilloma virus-polymerase chain reaction(HPV-PCR) reverse dot blot hybridization genotyping.Results In 3 253 cases,781 cases were HPV positive,the total positive rate was 24.01%,among which 22 kinds of sbutype were detected,which accounted for high-risk HPV 539 patients(69.01%),low-risk HPV 129 patients(16.52%),mixed HPV were 113 patients(14.47%).546 cases were the infection of single HPV subtype(69.91%),235 cases were the multiple infection of HPV subtypes(30.09%).The peak of HPV infection was at the ages less than 20,51 ~ 60 and more than 60 in the different age groups,infection rates were respectively 37.50%,31.39% and 26.84%.The main infection subtypes were HPV16,HPV52,HPV58,HPV81,HPV33,HPV18.Conclusion The infection of HPV type turns to be universal.Differences of positive rates among different ages were statistically significant(P < 0.05).More attention should be paid to women less than 20 years old and more than 60 years old and the regular random visit to the positive patientsshould be strengthened.The detection of HPV subtypes for fertile women helps the early warning and early treatment of cervical cancer.更多还原