【摘要】 目的了解山东省急性脑炎脑膜炎症候群(acute meningitis and encephalitis syndrome,AMES)的病原谱构成与流行病学特征。方法对2012年山东省济南市6所哨点医院采集的AMES病例的血清和脑脊液标本开展8种病毒IgM抗体检测,部分CSF进行肠道和乙脑病毒分离。结果全年共报告AMES病例629例,99.2%采集了血和/或CSF标本(624/629),病原谱中的前几位依次是单纯疱疹病毒、人类肠道病毒、流行性腮腺炎病毒、流行性乙型脑炎病毒、巨细胞病毒、风疹病毒,阳性率分别为20.92%、13.35%、11.35%、8.01%、4.78%、3.58%。另外还有少数水痘-带状疱疹病毒、麻疹病毒感染病例。结论单纯疱疹病毒、人类肠道病毒、流行性腮腺炎病毒、流行性乙型脑炎病毒仍然是2012年山东省AMES病例的主要病原,今后应加强病原学监测,探讨病原体的变异变迁规律。更多还原

【Abstract】 Objective To analyze the pathogenic spectrum constitution and epidemiological characteristics of acute meningitis and encephalitis syndrome( AMES) in Shandong. Methods All samples( serum and cerebrospinal fluid) of AMES cases from six sentinel hospitals of Jinan city were collected to test the specific IgM antibody to 8 kinds of virus by enzyme-linked immunosorbent assay( ELISA). Part of cerebrospinal fluid samples were performed JEV and HEV isolation. Results In 2012,629 AMES cases were reported,and 624 serum and / or CSF samples were collected( 99. 2%). The main viral pathogens were herpes simplex virus( HSV),human enterovirus( HEV),mumps virus( MuV),Japanese encephalitis virus( JEV),cytomegalovirus( CMV) and rubella virus( RV),and the positive rates were 20. 92%,13. 35%,11. 35%,8. 01%,4. 78%,3. 58% respectively. In addition,varicella-zoster virus( VZV) and measles virus( MV) were found in a small number of cases. Conclusion The AMES cases of Jinan city in 2012 were mainly caused by HSV,HEV,MuV and JEV as before. In the future,active surveillance and pathogen confirmation should be enhanced and the variation rules should be further studied.更多还原