【摘要】 目的:分析2013年医院临床分离病原菌分布和耐药性,为临床治疗经验性用药提供参考依据。方法:采用VITEK-2进行细菌鉴定和药物敏感试验测定,使用Whonet5.6软件进行数据统计分析。结果:2013年医院共分离出病原菌3977株,排名依次为大肠埃希菌(14.3%)、鲍曼不动杆菌(9.2%)、肺炎克雷伯菌(8.9%)、铜绿假单胞菌(8.8%)、凝固酶阴性葡萄球菌(7.6%)、金黄色葡萄球菌(7.3%)、粪肠球菌(4.6%)、屎肠球菌(3.5%),其中肠杆菌科菌中大肠埃希菌和肺炎克雷伯菌的耐碳青霉烯酶菌株检出率分别为0.9%(5/567)、3.1%(11/354);非发酵菌中鲍曼不动杆菌和铜绿假单胞菌对亚胺培南/美洛培南的耐药率分别57.2%/72.4%和21.5%/19.9%;葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率分别为50.0%(146/292)和78.7%(237/301),未发现对万古霉素、利奈唑胺、替加环素的耐药株;肠球菌属中耐万古霉素粪肠球菌和屎肠球菌检出率分别为0.6%(1/183)和20.7%(29/140),未发现替加环素的耐药株。结论:细菌耐药呈增长趋势,需加强耐药性监测,并有效控制抗菌药物的使用。更多还原

【Abstract】 Objective:To investigate the clinical pathogen distribution and resistance profile to antimicrobial agents from China-Japan Friendship Hospital in 2013.Methods:The identification and antimicrobial susceptibility test of the isolates were determined by VITEK-2.All the data were analyzed by Whonet 5.6 software.Results:3977 strains were isolated in 2013.The main pathogenic species were as follows:Escherichia coli(ECO)(14.3%),Acinetobacter baumannii(ABA)(9.2%),Klebsiella pneumoniae ss.Pneumoniae(KPN)(8.9%),Pseudomonas aeruginosa(PAE)(8.8%),coagulase-negative Staphylococcus(CNS)(7.6%),Staphylococcus aureus ss.Aureus(SAU)(7.3%),Enterococcus faecalis(EFA)(4.6%),Enterococcus faecium(EFM)(3.5%).The detection rate of carbapenemase-resistant Enterobacteriaceae(CRE)was 0.9%(5/567)in ECO and 3.1%(11/354)in KPN.The resistant rate of Imipenem and Meropenem in non-fermentative bacteria were 57.2% /72.4% in ABA and21.5%/19.9% in PAE.The detection rate of MRSA and MRCNS were 50.0%(146/292)and 78.7%(237/301),respectively.The detection rate of Vancomycin-resistant Enterococcus(VRE)was 0.6%(1/183)in EFA and 20.7%(29/140) in EFM.Conclusion:The resistance of bacteria is still increasing,surveillance of antimicrobial agents is very important.更多还原