【摘要】 核受体在后生动物中作为一类重要的转录调控因子,在一系列重要的生化过程中发挥重要的作用,包括细胞分化和增殖。核受体含共有的蛋白结构,包含一个N端-A/B区,一个高度保守的DBD,一个铰链区(D区)和一个C-端LBD区。到目前为止,寄生扁形动物中的核受体,只在曼氏血吸虫和日本血吸虫中有报道。本文对近年来血吸虫的核受体的研究成果做简要综述,以为今后更进一步的研究提供参考。更多还原

【Abstract】 Nuclear hormone receptors(NRs)belong to a large protein superfamily that are important transcriptional modulator in metazoan and play vital role in metabolism including cell differentiation and proliferation.NRs share a common tertiary structure,the typical NR contains an N-terminal A/B domain,a highly conserved DNA binding domain(DBD),a hinge(D domain),and a C-terminal ligand binding domain(LBD).The nuclear receptors in parasitic platyhelminths were reported so far only in the Schistosoma mansoni and Schistosoma japonicum.The aim of this review is to examine the current knowledge of nuclear receptors in parasitic platyhelminths that provide the reference for further research.更多还原