【摘要】 目的:探讨中国山东籍汉族大肠癌(CRC)患者人群中,IL-16基因多态性与大肠癌发病风险的关系。方法:在164例CRC患者和121名健康对照个体中,采用放大阻碍突变PCR(ARMS-PCR)方法对IL-16基因序列中的2个单核苷酸多态性(SNP)位点rs11556218和rs4778889进行基因分型,分析该2个位点的等位基因频率和基因型分布与CRC发病风险的关系。结果:在CRC患者中,rs11556218的T/G等位基因频率和基因型分布与对照组的差异有统计学意义(P=0.021 725,P=0.001 033);rs4778889的T/C等位基因频率及基因型分布与正常对照组的差异无统计学意义(P=0.057 946,P=0.064 229)。结论:IL-16的rs11556218基因多态性与可能与CRC的易感性增加有关。更多还原

【Abstract】 Objective:To investigate the relationship between interleukin 16(IL-16) gene polymorphism and risk of colorectal cancer(CRC) in Han nationality population in China’s Shandong province.Methods:From 164 CRC patients and 121 control healthy subjects,two single nucleotide polymorphism(SNP) sites,rs11556218 and rs4778889,in the IL-16 gene sequence were genotyped by means of amplification refractory mutation system(ARMS)-PCR.The relations of the allele frequency and distribution of the two polymorphic sites with CRC risk were analyzed.Results:In group of CRC patients,both theT/G allele frequency and distribution of rs11556218 were significantly different from control group(P=0.021 725,P=0.001 033),but the differences in theT/C allele frequency and distribution of rs4778889 had no statistical significance versus control group(P=0.057 946,P=0.064 229).Conclusion:IL-16 rs11556218 gene polymorphism is probably associated with the increased CRC susceptibility.更多还原