【摘要】 目的:观察维药神香草乙酸乙酯部位的抗炎、止咳、祛痰及平喘作用。方法:采用系统溶剂法对神香草醇提物进行初步分离,制备其乙酸乙酯部位;采用小鼠耳廓二甲苯致炎法、氨水喷雾致小鼠咳嗽法、小鼠气管酚红排泌法、2%氯化乙酰胆碱与0.1%组胺1:1混合液致豚鼠哮喘法进行实验。结果:神香草乙酸乙酯部位不同剂量可明显抑制二甲苯致小鼠的耳廓肿胀(P<0.05)、减少氨水喷雾致小鼠咳嗽次数(P<0.05)、促进小鼠气管酚红排泌(P<0.05)、豚鼠哮喘潜伏期明显延长(P<0.05),且其抗炎、止咳、祛痰及平喘作用均呈明显的剂量依赖关系(P<0.05)。结论:维药神香草乙酸乙酯部位具有显著的抗炎、止咳、祛痰、平喘作用。更多还原

【Abstract】 Objective: To study the anti-inflammatory,antitussive,expectorant and anti-asthmatic effects of Ethly Aectates from Uighur Medicine Hyssopus officinalis L. Methods: The anti-inflammatory effect was studied by the external ear swelling of mice induced by dimethyl benzene. The antitussive effect was studied by the cough model induced by ammonia inmice; the expectorant effect was studied by a mouse model of phenoled test; the anti-asthmatic effect was studied by a guinea pig model of asthma induced by such as volume of the mixture with 2% acetylcholine chloride and 0. 1% histamine phosphate. Results: The experimental results showed that Ethly Aectates could significantly inhibited xylene-induced ear edema in mice( P < 0. 05),reduced the number of ammonia spray-induced cough in mice( P < 0. 05),promoted the phenol red excretion of mousetracheal( P <0. 05),so that the latency was significantly prolonged in asthmatic guinea pigs( P < 0. 05) and it is showed Dose-dependent trend. Conclusion: The Ethly Aectates from Uighur Medicine Hyssopus officinalis L. have obvious the anti-inflammatory,antitussive,expectorant and anti-asthmatic effects.更多还原