【摘要】 目的:探索吸烟美沙酮维持治疗(Methadone Maintenance Treatment,MMT)门诊患者的烟草使用行为与生活质量的关系,以验证烟草依赖的"自我治疗假说"。方法:540例吸烟MMT患者完成尼古丁依赖严重程度量表(Fagerstrom Test for Nicotine Dependence,FTND)和中文版世界卫生组织生命质量量表简表(World Health Organization’s Quality of Life Questionnaire-Brief Version,Whoqol-BREF)调查,采用多元线性回归分析吸烟量、尼古丁依赖程度和吸烟年限与生活质量评分的关系。结果:多元线性回归分析显示,吸烟量与Whoqol-BREF的生理和心理领域评分负相关(β=-0.155~-0.161,P≤0.004);FTND评分与Whoqol-BREF的4个领域评分负相关(β=-0.339~-0.353,P均<0.001)。结论:吸烟MMT患者吸烟量越大和尼古丁依赖程度越重,生命质量越差,该发现不支持"自我治疗假说"。更多还原

【Abstract】 Objective: To explore relationship of tobacco use behavior and quality of life among outpatients with methadone maintenance treatment( MMT),and to test " self- medication hypothesis" of tobacco dependence. Methods: Five hundred and forty smokers with MMT were administered with the Chinese version of Fagerstrom test for nicotine dependence( FTND) scale and the world health organization’s quality of life questionnaire-brief version( Whoqol-BREF). Multiple linear regression was used to analyze the relationships among daily cigarette number,nicotine dependence,smoking history and Whoqol-BREF score. Results: The multiple linear regression revealed that the scores of physical and mental domains of Whoqol-BREF were negatively correlated with daily cigarette number( β =-0. 155 ~-0. 161,P≤0. 004),and the scores of four domains of Whoqol-BREF were negatively correlated with FTND score( β =-0. 339 ~-0. 353,all P<0. 001). Conclusions: Smokers with MMT with higher daily cigarette number have more severe nicotine dependence and worse quality of life. Moreover,these findings don’t support the self-medication hypothesis.更多还原