【摘要】 目的:评价血清抗瓜氨酸抗体(抗CCP-Ab)、抗角质蛋白抗体(AKA)及类风湿因子(RF)这3种指标在RA中的诊断意义。方法:通过对256例RA患者、92例其他自身免疫病患者、50例健康人进行抗CCP-Ab、AKA、RF检测,并对结果进行分析。结果:单指标检测,诊断RA的敏感性由高到低依次为RF、抗CCP-Ab、AKA,特异性由高到低依次为AKA、抗CCPAb、RF,联合检测以抗CCP-Ab和AKA联合检测的诊断效率最大。结论:RF、AKA、抗CCP-Ab三种指标在RA诊断方面各有优缺点,AKA、抗CCP-Ab对RF血清阴性的RA的诊断是一个有力补充,按照自己的实验条件选择适当的项目组合,对RA的早期诊断和尽早正规治疗,改善预后有较高的价值。更多还原

【Abstract】 Objective: To evaluate the value of serum anti citrullinated antibody( anti CCP-Ab),anti keratin antibody( AKA)and rheumatoid factor( RF) diagnostic significance of these 3 kinds of index in RA. Methods: 256 patients with RA,92 patients with other autoimmune diseases,50 cases of healthy people were anti CCP-Ab,AKA,RF detection,and the results were analyzed. Results:single target detection,diagnostic sensitivity of RA from high to low was RF,anti CCP-Ab,AKA,specific from high to low was AKA,anti CCP-Ab,RF,anti CCP-Ab and AKA combined detection in clinical diagnostic efficiency. Conclusion: RF,AKA,anti CCP-Ab three index have advantages and disadvantages in diagnosis of RA,the diagnosis of AKA,anti CCP-Ab serum of RF negative RA is a powerful complement to,in accordance with the selection of project portfolio appropriate experimental conditions,the early diagnosis of RA and early treatment,improve the prognosis had higher value.更多还原