【摘要】 目的观察个体化临床营养疗法强化干预对新诊断的糖尿病前期人群的转归及影响因素。方法选取2012年7月上海市虹口区社区糖尿病高危人群中,新筛查并诊断为糖尿病前期患者70例,以社区为单位分为临床营养治疗组(干预组)35例和常规随访组(对照组)35例。对照组进行常规健康教育,干预组进行每2个月1次的个体化膳食分析、营养指导以及糖尿病健康教育。随访8个月分析转归及影响因素。结果 8个月后,干预组在体质指数、体脂率、餐后2 h血糖、收缩压、舒张压、总胆固醇的下降程度与对照组比较,差异均有统计学意义(P<0.05)。两组各有1例(2.86%)进展为糖尿病,但干预组有31例(88.57%)患者逆转为正常糖耐量(NGT);对照组仅1例(2.86%),两组逆转率差异有统计学意义(P<0.01)。logistic逐步回归分析发现,体脂率、总胆固醇值的下降与糖尿病前期逆转为NGT呈独立正相关(P<0.05)。结论临床营养干预可显著增加糖尿病前期人群的NGT逆转率。体脂率、总胆固醇值的下降是糖尿病前期人群逆转为NGT的重要影响因素。更多还原

【Abstract】 Objective To observe the outcome and related risk factors of pre-diabetes patients interfered by individualized clinical nutritional therapy(CNT).Methods In the residents with high risk of diabetes of Hongkou district in Shanhai,70 cases were screened and diagnosed as pre-diabetes in July of 2012,who were divided into the CNT intervention group(35 cases) and control group(35 cases) according to communities.The conventional education was conducted in control group.The individualized diet analysis,nutritional direction and diabetic health education were performed every two months in CNT intervention group for 8months.Results After individualized CNT for 8 months,the body mass index(BMI),body fat rate,2 h-postprandial glucose,systolic blood pressure(SBP),diastolic blood pressure(DBP),total cholesterol(TC) in CNT intervention group significantly decreased,as compared with control group(P<0.05).One case(2.86%) in each group developed into diabetes mellitus.But 31 cases(88.75%)and 1 case(2.86%) in CNT intervention group and control group reverted to normal glucose tolerance(NGT),there was significant difference(P<0.01).Logistic analysis showed that the decreases of body fat rate and TC were positively correlated to the reversion of pre-diabetes(P<0.05).Conclusion The individualized CNT intervention could significantly increase the reversion rate of prediabetes to NGT.The decreases of body fat rate and TC are the important influent factors for reversion of pre-diabetes to NGT.更多还原