【摘要】 目的探讨125碘放射粒子植入术治疗老年晚期直肠癌的临床疗效及其相关因素。方法对已经不能手术切除老年晚期直肠癌20例实施125碘放射粒子植入手术,比较分析了术后肿瘤局部控制率、生存率、并发症及其相关影响因素。结果本组病例中,CR2例(10%);PR12例(60%):AC5例(25%);PD1例(5%);有效率70%。平均缓解期4个月(相当于125碘粒子2个半衰期),肿瘤局部中位控制率为12个月。术后1、2、3年实际局部控制率为39%、15%和10%,术后1、2、3年生存率分别为60%、32%和16%。肿瘤体积大、植入粒子总活度高、未能实施减瘤切除手术、年龄偏大及体质虚弱等导致术后生存率降低。结论125碘放射粒子植入术可以作为老年直肠癌有效、安全、并发症较少的姑息治疗方法。更多还原

【Abstract】 Objective To evaluate the clinical efficacy and related factors of advanced rectal cancer in old ages treated by radiotherapy with iodine-125 seed brachytherapy.Methods Twenty old patients who suffered from advanced rectal cancer underwent radiotherapy with iodine-125 seed brachytherapy were selected,then the survival rate,complications and other related factors were compared and analyzed.Results In all 20 cases,completed response(CR)was 2 cases(10%),partial response was 12 cases(60%),stable disease was 5 cases(25%),progressive disease was 1 case(5%),effective rate was 70%.The average CR time was four months,which was two times the half-life of iodine-125,while the mean local control rate was 12 months.Postoperative local control rate and postoperative survival rate after 1,2,3 years were39%,15%,10%and 60%,32%,16%,respectively.The large tumor volume,high levels activity of total amount,failure to implement surgery,advanced age and feebleness leaded to a relatively low postoperative survival rate.Conclusion Radiotherapy with iodine-125 seed brachytherapy is an effective,safe,less-complications palliative treatment for advanced rectal cancer in the older.更多还原