Pyruvate dehydrogenase is a key enzyme which transforms pyruvate into acetyl-coenzyme A(acetyl-CoA) by pyruvate decarboxylation. Acetyl coenzyme A is the primary raw material for aerobic oxidation of glucose into the Krebs cycle. The activity of pyruvate dehydrogenase can be negatively regulated by pyruvate dehydrogenase kinase. The overall expression of pyruvate dehydrogenase kinase is increased in tumor cells, which results in the decreasing activity of pyruvate dehydrogenase with an increased glycolysis ...
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