【摘要】 目的了解金华地区系统性红斑狼疮(SLE)患者一级亲属抗核抗体谱的分布及意义。方法收集SLE患者一级亲属162例以及80例健康体检者,分别检测自身抗核抗体谱、相关免疫学指标情况,并进行统计。结果 162例SLE患者一级亲属中,确诊为SLE 6例,3例为先证者母亲,2例为先证者姐妹,1例为先证者子女,其患病率为3.7%,同时确诊干燥综合征(SS)2例、混合型结缔组织病(MCTD)1例。剔除以上9例患者,其余153例"健康"一级亲属中ANA阳性15例(9.8%),抗Ro52阳性8例(5.2%),抗核小体阳性3例(2.0%),抗SSA阳性6例(3.9%),抗nRNP阳性9例(5.9%),抗心磷脂抗体IgG阳性11例(7.2%),抗心磷脂抗体IgM阳性3例(2.0%),抗ds-DNA阳性12例(7.8%);IgG升高10例(6.5%),IgM升高12例(7.8%),IgA升高3例(2.0%);补体C3下降9例(5.9%),补体C4下降6例(3.9%)。与健康对照组相比,SLE患者一级亲属中ANA、抗心磷脂抗体IgG、抗ds-DNA阳性率与健康对照组比较明显升高,差异均有统计学意义(均P<0.05),其余抗体及免疫球蛋白、补体的差异均无统计学意义(均P>0.05)。结论与正常人群相比,金华地区SLE患者一级亲属的ANA、抗心磷脂抗体IgG及抗ds-DNA阳性率明显升高,为狼疮的高危人群,需加强其筛查及随诊。更多还原

【Abstract】 Objective To investigate the distribution of antinuclear antibodies level in first-degree relatives(FDR) of patients with systemic lupus erythematosus(SLE).Methods Serum levels of antinuclear antibody and other autoantibodies were measured in 162 first-degree relatives of SLE patients and 80 healthy subjects in Jinhua region.Results Prevalence rate of SLE in first-degree relatives was 3.7%(6/162).Among remaining 152 non-SLE first-degree relatives,antinuclear antibody(ANA),anti-Ro52 antibody,anti-nucleosome,anti-Ro/SSA antibody,anti-nRNP antibody,anticardiolipin antibody(ACA)-lgG,ACA-IgM and anti-ds-DNA antibody were positive in 15 cases(9.8%),8 cases(5.2%),3 cases(2.0%),6 cases(3.9%),9 cases(5.9%),11 cases(7.2%),3 cases(2.0%),12 cases(7.8%),respectively.Higher positive rate of ANA,(ACA)-lgG and anti-ds-DNA antibody were found in FDR of SLE patients than healthy control group(P<0.05).Conclusion The first-degree relatives of SLE patients have higher positive rate of ANA,(ACA)-lgG and anti-ds-DNA antibody,indicating high risk of SLE for FDRs.更多还原