【摘要】 目的评价入院时测定的D-二聚体和C反应蛋白(CRP)水平对轻中型急性胰腺炎(AP)胰腺坏死的预测作用。方法测定62例发病72h内轻中型AP患者入院时D-二聚体和CRP水平,并用ROC曲线分析D-二聚体和CRP对胰腺坏死的预测作用。结果D-二聚体和CRP水平在多数患者中升高。ROC曲线分析结果显示D-二聚体和CRP水平均可以有效预测胰腺坏死的发生,曲线下面积分别达到0.927和0.961;其中D-二聚体水平在有无发生胰腺坏死的患者之间差异明显(P<0.001),其预测精确性也略高于CRP。结论无论是D-二聚体还是CRP水平,对轻中型AP患者的胰腺坏死均有一定的预测作用,D-二聚体的预测精确性更高。更多还原

【Abstract】 Objective To assess the predictive value of D-dimer and C-reactive protein(CRP) for pancreatic necrosis in patients with mild to moderate acute pancreatitis.Methods Sixty two patients with acute pancreatitis admitted to Longsai Hospital between November 2008 and May 2011 were included in the study.Serum D-dimer and CRP levels were measured in all patients at admission.Patients received standard treatment and the clinical parameters including complications,length of hospital stay were recorded.Results D-dimer and CRP levels were elevated in most patients at admission.The areas under ROC curve of D-dimer and CRP in predicting the pancreatic necrosis were 0.961 and 0.927,respectively.D-dimer level in patients with pancreatic necrosis was significantly higher than that in those without pancreatic necrosis(P<0.001) and D-dimer also presented better predictive accuracy.Conclusion Both D-dimer and CRP can well predict pancreatic necrosis in patients with mild to moderate acute pancreatitis.更多还原