【摘要】 目的探讨乳腺癌肌间淋巴结(IPN)转移的高危因素。方法收集行乳腺癌改良根治术的782例患者(均行IPN切除)的资料,选择年龄、肿瘤位置、肿瘤大小、腋窝淋巴结转移、脉管(血管、淋巴管)侵犯、病理类型、分子分型、Ki-67共8个乳腺癌内乳淋巴结转移可能相关的因素,分析不同情况下IPN转移的高危因素。结果全组患者IPN检出率21.0%,转移率6.9%;单因素分析显示,IPN的转移与肿瘤大小、腋窝淋巴结转移数目、脉管(血管、淋巴管)侵犯、病理类型、Ki-67明显相关(P<0.05),而与年龄、肿瘤位置及分子分型无明显关系(P>0.05)。logistic多因素回归分析显示,仅腋窝淋巴结转移和脉管侵犯是IPN转移的独立高危因素(均P<0.01),其中腋窝淋巴转移是最重要的危险因素。结论肿瘤大小、腋窝淋巴结转移、脉管(血管、淋巴管)侵犯、病理类型、Ki-67是乳腺癌IPN转移的危险因素,腋窝淋巴结转移及脉管侵犯与否是影响IPN转移的独立高危因素。更多还原

【Abstract】 Objective To assess the risk factors of interpectoral lymph nodes metastasis in breast cancer patients.Methods The clinical data of 782 breast cancer patients,who underwent modified radical mastectomy with interpectoral lymph nodes removed,were analyzed retrospectively.Eight individual variables,including age,tumor site,tumor size,axillary node metastasis status,vascular invasion,pathological type,molecular classification and Ki-67 expression were selected for investigating high risk factors of interpectoral lymph node metastasis.Results The detection rate and metastasis rate of interpectoral lymph nodes were 21.0% and 6.9%,respectively.Univariate analysis showed that patient age,tumor site,molecular classification were not significantly correlated with metastasis of interpectoral lymph nodes in breast cancer(P >0.05).Tumor size,axillary nodes metastasis status,vascular invasion,pathological type and Ki-67 expression were positively associated with metastasis of interpectoral lymph nodes(P<0.05).Multivariate logistic regression showed that vascular invasion and axillary nodes metastasis were independent risk factors for interpectoral lymph node metastasis in breast cancer(P<0.01).Conclusion The tumor size,axillary nodes metastasis status,vascular invasion,pathological type and Ki-67 are among the risk factors of interpectoral lymph nodes metastasis in breast cancer,however,only the vascular invasion and axillary nodes metastasis are independent risk factors.更多还原