【摘要】 目的探讨脑梗死患者血清胰岛素样生长因子-1(IGF-1)与颈动脉粥样硬化斑块的关系。方法选取100例急性脑梗死患者及50例健康对照者,采用ELISA法测定血清IGF-1水平,并进行颈动脉彩超检查,根据结果分成不稳定斑块组、稳定斑块组、无斑块组三亚组。结果脑梗死组颈动脉粥样硬化斑块及不稳定斑块的检出率分别为67.0%及42.0%,均明显高于对照组26.0%和8.0%,P<0.01。不稳定斑块组的血清IGF-1水平明显低于稳定斑块组及无斑块组(均P<0.01),稳定斑块组血清IGF-1水平明显低于无斑块组(P<0.05)。结论脑梗死患者的颈动脉粥样硬化斑块发生率明显增高;血清IGF-1水平减少与不稳定性颈动脉粥样硬化斑块形成密切相关。更多还原

【Abstract】 Objective To investigate the relationship between serum levels of insulin-like growth factor-1(IGF-1)and carotid atheromatous plaques in patients with cerebral infarction.Methods One hundred patients with cerebral infarction and 50 healthy subjects were enrolled in the study.Serum IGF-1 levels were measured by ELISA and carotid artery was examined by ultrasonography in both groups.Patients with unstable plaque,stable plaque and non-plaque were classified by ultrasonic findings.Results The rate of carotid atheromatous plaque and unstable plaque in cerebral infarction patients were 67.0%and42.0%respectively,which were significantly higher than that in control group(26.0%and 8.0%,P<0.01).Serum IGF-1 level in unstable plaque group was significantly lower than that in stable plaque group and non-plaque group(P<0.01);while serum IGF-1 level in stable plaque group was significantly lower than that in non-plaque group(P<0.05).Conclusion The incidence of carotid atheromatous plaque in patients with cerebral infarction is markedly increased;which is associated with the decreased serum IGF-1 levels in oatients.更多还原