【摘要】 在辛可宁的作用下,以靛红衍生物(N-甲基-3-羟基-2-吲哚酮)和氰基苯乙烯衍生物为原料,1,3,5-三甲苯为溶剂,合成了一系列的新型的手性吲哚螺-2,3-二氢化呋喃衍生物.该反应产率较高(90%~99%),选择性较好,而且操作简单、后处理方便.产物的结构经红外光谱、核磁共振谱(1H,13C)及高分辨质谱法表征.更多还原

【Abstract】 A series of novel spirooxindol-2,3-dihydrofuran compounds were synthesized by the reaction of isatin derivatives( 3-hydroxy-1-methylindolin-2-one) and cinnamonitrile derivatives in mesitylene in the presence of cinchonine. The reaction had excellent yields,high enantioselectivity,simple operation and easy post-processing. The structures of the products were determined by IR,NMR(1H,13C) and HRMS analysis.更多还原