【摘要】 磷脂酰肌醇-3激酶(P13K)/丝氨酸-苏氨酸蛋白激酶(Akt)信号转导通路参与调节脑缺血-再灌注后半暗带区微血管的生成,为缺血性脑血管疾病的临床治疗提供了新的途径。本文从调控缺氧诱导因子(HIF)、细胞内皮生长因子(VEGF)等相关因子的表达,促血管内皮祖细胞(EPCs)归巢和血管内皮细胞(VEC)迁移等方面,就近年来有关P13K/Akt信号转导通路在脑缺血-再灌注微血管生成机制方面的研究进展做一综述。更多还原

【Abstract】 PI3K/Akt signaling pathway involving in the microvascular generation in ischemic penumbra after the cerebral ischemia-reperfusion provides a new way for the clinical treatment of ischemic cerebrovascular disease.This paper summarizes the newest research about the role of PI3K/Akt signaling pathway in the blood capillary generation after the cerebral ischemia- reperfusion by regulating the expression of HIF,VEGF and related factors and subsequently promoting vascular EPCs homing and VEC migration,etc.更多还原