Objective To explore the clinical usefulness of the serum fibrosis index in diagnosing damage to the liver parenchyma in patients with schistosomiasis. Methods A radioimmunoassay was performed on sera from patients with advanced and chronic schistosomiasis from 3counties in the Poyang Lake region where Schistosoma japonica is endemic.The fibrosis index was determined by combining procollagen Ⅲ(PCⅢ),laminin(LN),hyaluronidase(HA),and collagen typeⅣ(Ⅳ-C).Antibodies to and antigens of hepatitis B were detected ...
ROC curve of LN was highest(ROC晚=0.740,ROC慢=0.673),followed by a combined diagnosis(ROC晚=0.677,ROC慢=0.619).Conclusion The detection of HA is helpful for diagnosis of schistosomiasis in the early stages of in-fection.Combined determination of 4componen