Objective To determine and compare the sensitivity to praziquantel of cercariae of different geographical isolates of Schistosoma japonicumfrom marshland and lake regions of China. Methods Oncomelania snails infected with S.japonicum were collected from endemic foci in marshland and lake regions of China,including Hunan,Hubei,Jiangxi,Anhui,and Jiangsu provinces.Freshly released cercariae were collected and exposed to praziquantel at concentrations of 10-5,5×10-6,10-6,5×10-7,and 10-7 mol/L for 20,40,60,80,an...