【摘要】 目的通过分析住院新生儿使用抗菌药物情况,促进临床合理使用抗菌药物,遏制细菌耐药性,预防医院感染。方法回顾性调查2011年6-9月在新生儿科出院患儿使用抗菌药物情况,分析其合理性。结果使用抗菌药物876例,使用率76.9%,抗菌药物消耗量551.18DDD,抗菌药物使用强度5.0,抗菌药物特殊品种消耗量40.07DDD,特殊品种使用占7.3%;使用一、二及≥三联抗菌药物分别占88.4%、10.8%、0.8%;治疗用药、治疗+预防用药、预防用药分别占67.6%、4.9%、27.5%;治疗以及治疗+预防用药病原学送检率为98.1%,特殊用药病原学送检率为100.0%,共使用抗菌药物29种、1474例次,其中排名前10位的抗菌药物分别为头孢他啶、美洛西林、哌拉西林/他唑巴坦、氨苄西林、青霉素、亚胺培南/西司他丁、头孢呋辛、头孢唑林、红霉素及美罗培南,使用率依次为23.7%、21.6%、14.7%、11.9%、7.7%、3.5%、3.3%、3.3%、2.5%、1.4%。结论新生儿抗菌药物使用强度及联合用药规范、使用品种符合要求,抗菌药物使用率偏高是今后需要解决的问题。更多还原

【Abstract】 OBJECTIVE To analyze the use of antibiotics by the hospitalized neonates,promote the reasonable clinical use of antibiotics,curb the bacterial resistance,and prevent nosocomial infections.METHODS The use of antibiotics of the neonates who were discharged from the pediatrics department from Jun to Sep 2011was retrospectively analyzed,and the rationality was performed.RESULTS Totally 876neonates have used antibiotics with the utilization rate of 76.9%,the consumption of antibiotics was 551.18DDD,the use intensity of antibiotics was 5.0;the consumption of the special antibiotics was 40.07DDD,the cases of using such antibiotics accounted for 7.3%;the neonates for whom the one-drug therapy,two-drug therapy,and three-drug therapy were performed accounted for 88.4%,10.8%,and 0.8%,respectively.The neonates with the medication for treatment accounted for 67.6%,the neonates with medication for treatment plus prophylaxis 4.9%,the neonates with medication for prophylaxis 27.5%.The submission rate of etiology for the neonates with medication for treatment and treatment plus prophylaxis was 98.1%,the submission rate of etiology for the neonates with special medication was 100.0%.Of totally 29antibiotics used by 1474case-times of neonates,the ceftazidime,mezlocillin,piperacillintazobactam,ampicillin,penicillin,imipenem-cilastatin,cefuroxime,cefazolin,erythromycin,and meropenem ranked the top 10,the utilization rates were 23.7%,21.6%,14.7%,11.9%,7.7%,3.5%,3.3%,3.3%, 2.5%,and 1.4%,respectively.CONCLUSIONThe use intensity of antibiotics and combination medication for the neonates conform to the requirements for types of antibiotics,but the utilization rate of antibiotics is high,which needs to be solved.更多还原